Professor Karl Herholz MD, FRCP

Photograph of Karl Herholz

Professor of Clinical Neuroscience

The University of Manchester
Wolfson Molecular Imaging Centre
27 Palatine Road
M20 3LJ


Memberships of Committees and Professional Bodies

  • Royal College of Physicians, fellow
  • Royal Society of Medicine, fellow
  • Association of British Neurologists
  • British Neuro-Oncology Society
  • Deutsche Gesellschaft für Neurologie
  • Society of Cerebral Blood Flow and Metabolism
  • Manchester Medical Society
  • British Medical Association
  • Society of Nuclear Medicine
    • Brain Imaging Council, President (2010/2011)


  • Neuroimaging studies (PET and MRI) of
    • dementia (early diagnosis of dementia in patients with mild cognitive deficits, multicentre studies, impairment of specific transmitter systems and their relevance for cognitive symptoms and distinction of dementing disorders, monitoring of progression, clinical trials in collaboration with pharmaceutical companies)
    • brain tumors (grading of metabolic activity, detection of progression to higher grade of malignancy, interference with and plasticity of normal brain function, monitoring of therapy, 3D visualization for planning of neurosurgical intervention)
  • Coordination of International Multicentre Studies
    • Early Diagnosis of Neurodegenerative Diseases within the EU-funded Networks on Diagnostic Molecular Imaging ( and Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)
    • Chief investigator of the EU-funded "Network for Efficiency and Standardisation of Dementia Diagnosis" (NEST-DD) with a comprehensive clinical and neuroimaging digital database of more than 1000 subjects
    • Collaboration with the NIH-funded Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Methodological Knowledge

  • Functional neuroimaging, especially using positron emission tomography (PET)
  • Accredited expert in radiation protection (ARSAC)


  • Graduation as medical doctor at the University of Erlangen, Germany, in 1980
  • After basic general clinical training, clinical research fellow at the Max-Planck-Institute for Neurological Research in Cologne, Germany, since 1982
  • Clinical specialist training in neurology at municipal and university hospitals, Cologne, Germany, from 1982 to 1990
  • Since 1994 professor of neurology at the University of Cologne
  • Since 2005, after moving to the University of Manchester, UK, professor in clinical neuroscience and head of the neuroscience imaging programme at the Wolfson Molecular Imaging Centre (WMIC)
  • WMIC director from April 2006 to July 2010


  • Doctor of medicine (, University of Erlangen, Germany
  • Specialist board examination in neurology, Duesseldorf, Germany
  • Habilitation and Venia legendi in neurology, University of Cologne, Germany




  • Firbank, M. J., Lloyd, J., Williams, D., Barber, R., Colloby, S. J., Barnett, N., ... O'Brien, J. T. (2015). An evidence-based algorithm for the utility of FDG-PET for diagnosing Alzheimer's disease according to presence of medial temporal lobe atrophy.The British journal of psychiatry : the journal of mental science. DOI:10.1192/bjp.bp.114.160804. Publication link: a5dd2904-1514-495b-96dd-5fbff61b2149 | PubMed:26045347
  • Lista, S., Molinuevo, J. L., Cavedo, E., Rami, L., Amouyel, P., Teipel, S. J., ... Hampel, H. (2015). Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline.Journal of Alzheimer's disease : JAD, 48 Suppl 1. DOI:10.3233/JAD-150202. Publication link: 8eee1f23-1b36-4f00-9d65-7528877d7091 | PubMed:26402088
  • O'Brien, J. T., & Herholz, K. (2015). Amyloid imaging for dementia in clinical practice.BMC Medicine, 13. DOI:10.1186/s12916-015-0404-6. Publication link: 12234750-653c-4017-b8ce-f0f712e99e0e | PubMed:26170121
  • Su, Z., Roncaroli, F., Brodbelt, A., Jackson, A., Gerhard, A., Herholz, K., ... Du Plessis, D. (2015). The 18-kDa Mitochondrial Translocator Protein in Human Gliomas: An 11C-(R)PK11195 PET Imaging and Neuropathology Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(4), 512-7. DOI:10.2967/jnumed.114.151621 jnumed.114.151621 [pii], 10.2967/jnumed.114.151621. Publication link: dec3774b-b00c-4c22-9dbe-66eeafa9df21 | PubMed:25722450
  • Kobylecki, C., Gerhard, A., Herholz, K., & Saba, L. (Ed.) (2015). Positron emission tomography in neurodegenerative disorders - evolving techniques and new tracers. In Imaging in neurodegenerative disorders. (pp. 135-150). Oxford: Oxford University Press. . Publication link: 9405c929-0110-4c12-a67c-454d7a06e0f8


  • Caroli, A., Prestia, A., Wade, S., Chen, K., Ayutyanont, N., Landau, S. M., ... Frisoni, G. B. (2014). Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI.Alzheimer disease and associated disorders. DOI:10.1097/WAD.0000000000000071. Publication link: e7e61763-607d-4ffb-b4e1-6cad96a28472 | PubMed:25437302
  • Carter, S. F., Embleton, K. V., Anton-Rodriguez, J. M., Burns, A., Ralph, M. A. L., & Herholz, K. (2014). Regional neuronal network failure and cognition in late-onset sporadic Alzheimer disease. American Journal of Neuroradiology, 35(6 SUPPL.), S18-S30. DOI:10.3174/ajnr.A3895. Publication link: 9aad61d1-c202-48f7-932f-b1996cb9d93b | PubMed:24578281
  • Cavedo, E., Lista, S., Khachaturian, Z., Aisen, P., Amouyel, P., Herholz, K., ... Hampel, H. (2014). The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations.The journal of prevention of Alzheimer's disease, 1(3). DOI:10.14283/jpad.2014.32. Publication link: 8faa9885-d0a2-44d6-9472-8c4a11c712ee | PubMed:26478889
  • Herholz, K. (2014). Guidance for reading FDG PET scans in dementia patients.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology, 58(4). . Publication link: 1f5dcf0a-ce0a-4e30-b3c5-e8f8a34c1ac5 | PubMed:25391316
  • Kerklaan, B. J., Berckel, B. N., Herholz, K., Dols, A., Flier, W. M., Scheltens, P., & Pijnenburg, Y. A. (2014). The Added Value of 18-Fluorodeoxyglucose-Positron Emission Tomography in the Diagnosis of the Behavioral Variant of Frontotemporal Dementia. Am J Alzheimers Dis Other Demen, doi:10.1177/1533317514524811. DOI:10.1177/1533317514524811. Publication link: 4fd2a538-e15e-4d50-be68-5bb58e9ce847
  • O'Brien, J. T., Firbank, M. J., Davison, C., Barnett, N., Bamford, C., Donaldson, C., ... Lloyd, J. (2014). 18F-FDG PET and Perfusion SPECT in the Diagnosis of Alzheimer and Lewy Body Dementias.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(12). DOI:10.2967/jnumed.114.143347. Publication link: 3cc1976d-66b4-4ebd-8edb-eeff37db9340 | PubMed:25453043
  • Herholz, K., Dierckx, R. A. (Ed.), Otte, A. (Ed.), De Vries, E. G. (Ed.), Van Waarde, A. (Ed.), & Leenders, K. L. (Ed.) (2014). Gliomas. In PET and SPECT in Neurology. (pp. 863-880). Heidelberg: Springer. . Publication link: 445375ff-461e-400e-8d63-cacccfdcb563






  • Haense, C., Herholz, K., Jagust, W. J., & Heiss, W. D. (2009). Performance of FDG PET for detection of Alzheimer's disease in two independent multicentre samples (NEST-DD and ADNI). Dementia and Geriatric Cognitive Disorders, 28(3), 259-266. DOI:10.1159/000241879. Publication link: 29473718-4553-466c-84ef-3eb5c70a7d3e
  • Markiewicz, P. J., Matthews, J. C., Declerck, J., & Herholz, K. (2009). Robustness of multivariate image analysis assessed by resampling techniques and applied to FDG-PET scans of patients with Alzheimer's disease. NeuroImage, 46(2), 472-485. DOI:10.1016/j.neuroimage.2009.01.020. Publication link: be867afa-f9cc-44f2-a865-6ef54e4046da
  • Salmon, E., Kerrouche, N., Perani, D., Lekeu, F., Holthoff, V., Beuthien-Baumann, B., ... Herholz, K. (2009). On the multivariate nature of brain metabolic impairment in Alzheimer's disease. Neurobiology of Aging, 30(2), 186-197. DOI:10.1016/j.neurobiolaging.2007.06.010. Publication link: 40276566-d7ba-4c5b-aaea-a6252e3e53f8
  • Ullrich, R. T., Kracht, L., Brunn, A., Herholz, K., Frommolt, P., Miletic, H., ... Jacobs, A. H. (2009). Methyl-L-11C-methionine PET as a diagnostic marker for malignant progression in patients with glioma. Journal of Nuclear Medicine, 50(12), 1962-1968. DOI:10.2967/jnumed.109.065904. Publication link: af23cc42-7569-43f9-b7a8-bbbc63ca7b9f
  • Herholz, K., Jagust, W. (Ed.), & D'Esposito, M. (Ed.) (2009). Functional imaging with FDG-PET in mild cognitive impairment. Imaging the Aging Brain. In Imaging the Aging Brain. (pp. 183-190). Oxford: Oxford University Press. . Publication link: 411f14df-7dab-45a9-ad5a-6fdb67962853



  • Eggers, C., Szelies, B., Bauer, B., Wienhard, K., Schröder, H., Herholz, K., & Heiss, W. D. (2007). Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulness. European Journal of Neurology, 14(6), 690-693. DOI:10.1111/j.1468-1331.2007.01737.x. Publication link: cc4211d0-c915-422e-89bb-d920a3e1e1fd
  • Herholz, K. G., Coope, D. J., Cizek, J., Eggers, C., Vollmar, S., & Heiss, W. (2007). Evaluation of Primary Brain Tumors Using 11C-Methionine PET with Reference to a Normal Methionine Uptake Map.Journal of Nuclear Medicine, 48(12). . Publication link: 86f76475-9b5c-415e-9d39-eec26a134579
  • Herholz, K., Carter, S. F., & Jones, M. (2007). Positron emission tomography imaging in dementia. British Journal of Radiology, 80(2), S160-S167. DOI:10.1259/bjr/97295129. Publication link: bd0a11aa-d055-4570-850c-05d6c5e93807 | PubMed:18445746
  • Herholz, K., Coope, D., & Jackson, A. (2007). Metabolic and molecular imaging in neuro-oncology. The Lancet Neurology, 6(8), 711-724. DOI:10.1016/S1474-4422(07)70192-8. Publication link: 65bc7aee-9137-4120-ab17-c6ddceb93c5f | PubMed:17638612
  • Herting, B., Beuthien-Baumann, B., Pöttrich, K., Donix, M., Triemer, A., Lampe, J. B., ... Holthoff, V. A. (2007). Prefrontal cortex dysfunction and depression in atypical Parkinsonian syndromes. Movement Disorders, 22(4), 490-497. DOI:10.1002/mds.21237. Publication link: 936a0e79-1bba-434e-9748-ac6c8fec1662
  • Rueger, M. A., Kracht, L. W., Hilker, R., Thiel, A., Sobesky, J., Winkeler, A., ... Jacobs, A. H. (2007). Role of in vivo imaging of the central nervous system for developing novel drugs. Quarterly Journal of Nuclear Medicine and Molecular Imaging, 51(2), 164-181. . Publication link: 22e02c32-cba1-459e-940c-71405be27cf2
  • Herholz, K. G., Price, P. M., & Coope, D. J. (2007). Brain tumours: planning and monitoring therapy with PET.In In: Cancer Imaging, Hayat M (ed).. Elsevier Science. . Publication link: a66edf1d-6eb0-43ec-96a5-83e298f0eecf
  • Herholz, K. G., Vollmar, S., Hampl, J. A., & Kracht, L. (2007). Integration of Functional Data (PET) into Brain Surgery Planning and Neuronavigation. In Advances in Medical Engineering. Springer. . Publication link: c802cfad-187c-4854-9c3d-af1e9509e0ed


  • Herholz, K. G., Morris, C. M., & Perani, D. (2006). The dementias: early diagnosis and evaluation. Taylor & Francis.. Publication link: 006ee6ba-0d8b-49b8-ac78-43a8015434c3
  • Eggers, C., Herholz, K., Kalbe, E., & Heiss, W. D. (2006). Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease. Neuroscience Letters, 408(1), 46-50. DOI:10.1016/j.neulet.2006.08.061. Publication link: bb2121c6-5324-400a-95be-e9d130320cae
  • Galldiks, N., Kracht, L. W., Burghaus, L., Thomas, A., Jacobs, A. H., Heiss, W. D., & Herholz, K. (2006). Use of 11C-methionine PET to monitor the effects of temozolomide chemotherapy in malignant gliomas. European Journal of Nuclear Medicine and Molecular Imaging, 33(5), 516-524. DOI:10.1007/s00259-005-0002-5. Publication link: 81ca4391-13b7-4f4d-9502-c79bcfaf8676
  • Herholz, K. (2006). Cognitive dysfunction and emotional-behavioural changes in MS: The potential of positron emission tomography. JOURNAL OF THE NEUROLOGICAL SCIENCES, 245(1-2), 9-13. DOI:10.1016/j.jns.2005.09.012. Publication link: c18c53a4-33b2-4fcf-b2c1-b99dff8c1d71
  • Herholz, K. G., Kerrouche, N., Mielke, R., Holthoff, V., & Baron, J. (2006). 18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysis.J Cereb Blood Flow Metab, 26( 9). . Publication link: 75ede156-eb84-4604-8185-b7627de6e2c0
  • Herholz, K. G., Kracht, L. W., Vollmar, S., & Jacobs, A. H. (2006). Brain Tumors: Astrocytoma, Oligodendroglioma, and Glioblastoma Images with PET and SPECT. Molecular Anatomic Imaging: PET-CT and SPECT-CT Integrated Modality Imaging Lippincott. . Publication link: 6ecd63e5-1233-4552-9c94-ff1b61c9698a
  • Masdeu, J. C., Irimia, P., Asenbaum, S., Bogousslavsky, J., Brainin, M., Chabriat, H., ... Seitz, R. J. (2006). EFNS guideline on neuroimaging in acute stroke. Report of an EFNS task force. European Journal of Neurology, 13(12), 1271-1283. DOI:10.1111/j.1468-1331.2006.01507.x. Publication link: 41c8f5b4-4a27-4ef7-ac57-43150bcb63b6
  • Peters, F., Perani, D., Herholz, K., Holthoff, V., Beuthien-Baumann, B., Sorbi, S., ... Salmon, E. (2006). Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia. Dementia and Geriatric Cognitive Disorders, 21(5-6), 373-379. DOI:10.1159/000091898. Publication link: 56bfb335-92a7-45bc-9e88-154c6efa3d57
  • Salmon, E., Kerrouche, N., Herholz, K., Perani, D., Holthoff, V., Beuthien-Baumann, B., ... Garraux, G. (2006). Decomposition of metabolic brain clusters in the frontal variant of frontotemporal dementia. NeuroImage, 30(3), 871-878. DOI:10.1016/j.neuroimage.2005.10.016. Publication link: 1cf3e6d7-4b5a-4208-af86-1358950f7bd3
  • Salmon, E., Perani, D., Herholz, K., Marique, P., Kalbe, E., Holthoff, V., ... Garraux, G. (2006). Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease. Human Brain Mapping, 27(7), 588-597. DOI:10.1002/hbm.20203. Publication link: 81cff936-1915-4204-b1fa-c395a142dc66
  • Thiel, A., Habedank, B., Herholz, K., Kessler, J., Winhuisen, L., Haupt, W. F., & Heiss, W. D. (2006). From the left to the right: How the brain compensates progressive loss of language function. Brain and Language, 98(1), 57-65. DOI:10.1016/j.bandl.2006.01.007. Publication link: 27f08c79-6ec1-4fa7-ad65-6664191b5f5b
  • Herholz, K. G. (2006). Positron emission tomography (PET) ligands and metabolic brain imaging. In Neurodegenerative Diseases. Henry Stewart Talks. . Publication link: 831d9a57-6675-4514-95fb-cb274392f905
  • Coope, D. J., Herholz, K. G., Vollmar, S., Eggers, C., & Heiss, W. D. (2006). Development of a normal 11C-methionine PET uptake map: a novel approach to the evaluation of brain tumors using PET. 371-371. Poster session presented at Seventh Congress of the European Association for Neuro-Oncology, Vienna, Austria, .10.1215/15228517-2006-019. Publication link: e790aba2-e207-4e91-9ae3-4cc635093f85


  • Anchisi, D., Borroni, B., Franceschi, M., Kerrouche, N., Kalbe, E., Beuthien-Beumann, B., ... Perani, D. (2005). Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to alzheimer disease. Archives of Neurology, 62(11), 1728-1733. DOI:10.1001/archneur.62.11.1728. Publication link: 5a984237-7d76-40bc-81d3-78bc59386aca
  • Herholz, K. (2005). Action of cholinesterase inhibitors in patients' brains. Journal of Neurology, Neurosurgery and Psychiatry, 76(3), 305. DOI:10.1136/jnnp.2004.048405. Publication link: 21b6c4bd-184e-4ce9-b586-b1dfef8f7a33
  • Herholz, K. G., Cizek, J., & Schrader, R. (2005). Robust non-linear registration of 3D medical images with one-to-one deformations.Neuroimage. . Publication link: 352910dd-0f04-40af-8abe-c069d7b1bed1
  • Herholz, K. G., Habedank, B., Wallesch, C. W., & Forstl, . U. (2005). Funktionelle bildgebende Diagnostik.Demenzen. . Publication link: 6f9d6f65-e32a-4edb-9937-3e157228b62b
  • Herholz, K. G., Mosconi, L., Pupi, A., Prohovnik, I., Nacmias, B., De, C. M. T. R., ... Sorbi, S. (2005). Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve. Journal of Neurology, Neurosurgery and Psychiatry, 76 (1). . Publication link: 9c2e111d-d203-4240-91ed-182c9fbf09c5
  • Herholz, K. G., Thiel, A., Haupt, W. F., Habedank, B., Winhuisen, L., & Kessler, J. (2005). Neuroimaging guided rTMS of left inferior frontal gyrus interferes with repetition priming. Neuroimage, 25 (3). . Publication link: 1c2bae28-9812-4628-b505-8108b3fcfef7
  • Herholz, K., Hilker, R., Portman, A. T., Voges, J., Staal, M. J., Burghaus, L., ... Leenders, K. L. (2005). Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation. Journal of Neurology, Neurosurgery and Psychiatry. . Publication link: 01271ae0-4911-485b-b85d-f81bd94aff02
  • Herholz, K., Holthoff, V. A., Beuthien-Baumann, B., Kalbe, E., Ludecke, S., Lenz, O., ... KG, . U. (2005). Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression. Biol Psychiatry, 57 (4). . Publication link: 8407afa4-3491-482c-a683-be992823ac54
  • Herholz, K., Salmon, E., Lespagnard, S., Marique, P., Peeters, F., KG, . U., ... Garraux, G. (2005). Cerebral metabolic correlates of four dementia scales in Alzheimer's disease. Journal of Neurology Epub. . Publication link: 0bf0d0ab-234f-46a3-b54f-245c8c59c1ab
  • Herholz, K., Weisenbach, S., Kalbe, E., Diederich, N. J., & Heiss, W. D. (2005). Cerebral acetylcholine esterase activity in mild cognitive impairment. NeuroReport, 16(13), 1431-1434. DOI:10.1097/01.wnr.0000177007.21732.7b. Publication link: f96e20dc-f416-4951-8197-192f8ad5381d
  • Hilker, R., Schweitzer, K., Coburger, S., Ghaemi, M., Weisenbach, S., Jacobs, A. H., ... Heiss, W. D. (2005). Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity. Archives of Neurology, 62(3), 378-382. DOI:10.1001/archneur.62.3.378. Publication link: f67a8d83-a689-4e8c-947f-b2c9cd7e7bfd
  • Hilker, R., Thomas, A. V., Klein, J. C., Weisenbach, S., Kalbe, E., Burghaus, L., ... Heiss, W. D. (2005). Dementia in Parkinson disease: Functional imaging of cholinergic and dopaminergic pathways. Neurology, 65(11), 1716-1722. DOI:10.1212/01.wnl.0000191154.78131.f6. Publication link: ada162ce-16ca-48d9-b5c0-ddf9ddbdc9ae
  • Jacobs, A. H., Kracht, L. W., Gossmann, A., Rüger, M. A., Thomas, A. V., Thiel, A., & Herholz, K. (2005). Imaging in neurooncology. NeuroRx, 2(2), 333-347. DOI:10.1602/neurorx.2.2.333. Publication link: ca48be6f-ed40-4aec-a16c-549bfc38fc49
  • Jacobs, A. H., Thomas, A., Kracht, L. W., Li, H., Dittmar, C., Garlip, G., ... Heiss, W. D. (2005). 18F-fluoro-L-thymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumors. Journal of Nuclear Medicine, 46(12), 1948-1958. . Publication link: 31f86196-c0c3-4ff2-8cae-c05678d5593c
  • Kalbe, E., Salmon, E., Perani, D., Holthoff, V., Sorbi, S., Elsner, A., ... Herholz, K. (2005). Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 19(5-6), 349-356. DOI:10.1159/000084704. Publication link: aa637833-4eba-4ad0-ac6f-5928bbd362ed
  • Lange, C., Kracht, L., Herholz, K., Sachsse, U., & Irle, E. (2005). Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder. Psychiatry Research - Neuroimaging, 139(2), 115-126. DOI:10.1016/j.pscychresns.2005.05.003. Publication link: 85bf5616-37c2-4082-93a4-4f044a558aa0
  • Sobesky, J., Thiel, A., Ghaemi, M., Hilker, R. H., Rudolf, J., Jacobs, A. H., ... Heiss, W. D. (2005). Crossed cerebellar diaschisis in acute human stroke: A PET study of serial changes and response to supratentorial reperfusion. Journal of Cerebral Blood Flow and Metabolism, 25(12), 1685-1691. DOI:10.1038/sj.jcbfm.9600162. Publication link: f435825e-ae8b-49df-9584-70b9e1e964d2
  • Thiel, A., Habedank, B., Winhuisen, L., Herholz, K., Kessler, J., Haupt, W. F., & Heiss, W. D. (2005). Essential language function of the right hemisphere in brain tumor patients. Annals of Neurology, 57(1), 128-131. DOI:10.1002/ana.20342. Publication link: 02011497-20fe-4119-a269-d78b0096a420


  • Hartmann, P., Herholz, K., Salzberger, B., & Petereit, H. F. (2004). Unusual and severe symptomatic impairment of neutrophil function after one cycle of temozolomide in patients with malignant glioma. Annals of Hematology, 83(4), 212-217. DOI:10.1007/s00277-003-0802-2. Publication link: 7dbe80b8-2b1c-47f5-903c-2e478d376485
  • Heiss, W. D., Habedank, B., Klein, J. C., Herholz, K., Wienhard, K., Lenox, M., & Nutt, R. (2004). Metabolic rates in small brain nuclei determined by high-resolution PET. Journal of Nuclear Medicine, 45(11), 1811-1815. . Publication link: 73c46b9e-1d0e-4d07-ad3c-7f9a63e4c637
  • Herholz, K. G., & Heiss, W. D. (2004). PET in clinical neurology.Molecular Imaging & Biology, 6(4). . Publication link: 2ae2e5fa-89ca-4f04-886e-1bab8331a157
  • Herholz, K. G., Cizek, J., Vollmar, S., Schrader, R., Klein, J., & Heiss, W. D. (2004). Fast and robust registraion of PET and MR images of human brain.Neuroimage, 22(1). . Publication link: 3856d7d1-8483-436c-ad9e-c6a319a65298
  • Herholz, K. G., Galldiks, N., Burghaus, L., Vollmar, S., Cizek, J., Impekoven, P., ... Jacobs, A. H. (2004). Novel Neuroimaging Findings in a Patient with Cerebral Whipple's Disease: A magnetic Resonance Imaging and Positron Emission Tomography Study.Journal of Neuroimaging, 14(4). . Publication link: 4491ab9c-e703-43d7-a273-f282a13aeaf4
  • Herholz, K. G., Holthoff, V. A., Beuthien-Baumann, B., Zundorf, G., Triemer, A., Lundecke, S., ... Fuchtner, F. (2004). Changes in Brain Metabolism Associated with Remission in Unipolar Major Deprssion.Acta Psychiatr.Scand., 110(3). . Publication link: b8088239-4813-4471-8da7-7f406fe52734
  • Herholz, K. G., Mosconi, L., Nacmias, B., Sorbi, S., De, C. M. T., Fayazz, M., ... Pupi, A. (2004). Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 75(3). . Publication link: cf95036b-cd44-42db-b3bc-8c86341b2eec
  • Herholz, K. G., Mosconi, L., Pupi, A., De, C. M. T., Fayyaz, M., & Sorbi, S. (2004). Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's disease.The journal of Nuclear Medicine, 45(3). . Publication link: fac959e4-8320-4104-9ed4-42049a4a08e6
  • Herholz, K. G., Mosconi, L., Sorbi, S., Nacmias, B., De, C. M. T., Fayyaz, M., ... Pupi, A. (2004). Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study.Psychiatry Research: Neuroimaging, 130(2). . Publication link: c83f1ff8-c50e-435c-840e-d075fbe17387
  • Herholz, K., KG, . U., Zundorf, G., Bauer, B., Weisenbach, S., Heiss, W. D., ... Fisher, A. (2004). Measuring cerebral acetylcholine esterase activity in Alzheimer dementia by PET functional parametric imaging.Cholinergic Mechanisms. . Publication link: 16d7d78c-0ab6-47d5-a5ed-1c9bc0ffed0b
  • Herholz, K., Weisenbach, S., Zündorf, G., Lenz, O., Schröder, H., Bauer, B., ... Heiss, W. D. (2004). In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease. NeuroImage, 21(1), 136-143. DOI:10.1016/j.neuroimage.2003.09.042. Publication link: 323c13ad-909b-406d-82a0-ee4d00bd2da8
  • Hilker, R., Voges, J., Weisenbach, S., Kalbe, E., Burghaus, L., Ghaemi, M., ... KG, . U. (2004). Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson's disease.Journal of Cerebral Blood Flow & Metabolism, 24. . Publication link: 18192c75-e44f-4bce-8370-262a32a0d6cd
  • Kracht, L. W., Miletic, H., Busch, S., Jacobs, A. H., Voges, J., Hoevels, M., ... Heiss, W. D. (2004). Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: Local comparison with stereotactic histopathology. Clinical Cancer Research, 10(21), 7163-7170. DOI:10.1158/1078-0432.CCR-04-0262. Publication link: 47763939-71a4-448f-964e-59b2b65ddcb9
  • Mosconi, L., Perani, D., Sorbi, S., Herholz, K., Nacmias, B., Holthoff, V., ... Pupi, A. (2004). MCI conversion to dementia and the APOE genotype: A prediction study with FDG-PET. Neurology, 63(12), 2332-2340. . Publication link: f7603028-c711-4c64-b827-223741e715c1
  • Herholz, K. G., Herscovitch, P., & Heiss, W. D. (2004). NeuroPET. (NeuroPET). Berlin/Heidelberg/NY: Springer.. Publication link: 16297345-4992-44ce-9f3b-84f25d01ab96
  • Herholz, K. G., Vollmar, S., Cizek, J., Sue, M., Klein, J., Jacobs, A., ... Macho, V. (2004). VINCI -"Volume imaging in Neurological Research, Co-Registration and ROIs included". In Forschung and wissenschaftliches Rechnen 2003.. Publication link: 8d22f045-11de-4793-8059-481970c9daa3


  • Fesl, G., Moriggl, B., Schmid, U. D., Naidich, T. P., Herholz, K., & Yousry, T. A. (2003). Inferior central sulcus: Variations of anatomy and function on the example of the motor tongue area. NeuroImage, 20(1), 601-610. DOI:10.1016/S1053-8119(03)00299-4. Publication link: 255834a7-aa96-4075-804a-1d8cf4195368
  • Heiss, W. D., Thiel, A., Kessler, J., & Herholz, K. (2003). Disturbance and recovery of language function: Correlates in PET activation studies. NeuroImage, 20(1), S42-S49. DOI:10.1016/j.neuroimage.2003.09.005. Publication link: f9d0bc3a-c9b7-4392-bdc0-35d8dd9a9a42
  • Herholz, K. (2003). PET studies in dementia. Annals of Nuclear Medicine, 17(2), 79-89. . Publication link: d780869f-9659-453d-bc4b-f91b6b97b6a5
  • Herholz, K. G., Heiss, W. D., Thiel, A., Winhuisen, L., Muhlberger, B., & Kessler, J. (2003). Functional imaging in the assessment of capability for recovery after stroke.Journal of Rehabilitation Medicine, 35(Suppl). . Publication link: 479c9178-aa75-43a3-92dd-8dc21a37dfd1
  • Herholz, K. G., Kracht, L. W., Friese, M., Schroeder, R., Bauer, B., Jacobs, A., & Heiss, W. D. (2003). Methyl-[(11)C]- l-methionine uptake as measured by positron emission tomography correlates in microvessel density in patients with glioma.Eur.J Nucl Med Mol.Imaging, 30(6). . Publication link: 7791098b-dc07-4bd1-ae8c-11deed43fea3
  • Herholz, K. G., Kracht, L., & Heiss, W. D. (2003). Monitoring of the Effect of Chemotherapy in a Mixed Glioma by C-11-methionine PET. Journal of Neuroimaging, 13(3). . Publication link: c3bc6ef5-85a4-4a93-9f96-ea11a7c388b1
  • Herholz, K. G., Salmon, E., Garraux, G., Delbeuck, X., Collette, F., Kalbe, E., ... Fazio, F. (2003). Predominant ventromedial frontopolar metabolic impairment in frontoemporal dementia.Neuroimage, 20(1). . Publication link: 1318bc60-9997-48dd-9dfb-36819739a7ee
  • Herholz, K. G., Thiel, A., Hilker, R., Kessler, J., Habedank, B., & Heiss, W. D. (2003). Activation of basal ganglia loops in idiopathic Parkinson's disease: a PET study.J. Neural Transm., 110(11). . Publication link: 5bb2d139-bb48-4974-82fd-da16d402dc48
  • Herholz, K. G., Zundorf, G., Kerrouche, N., & Baron, J. C. (2003). An efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal aging.Hum.Brain Mapp, 18(1). . Publication link: ca6ef094-f1da-42d2-8b29-1585dfc158ac
  • Herholz, K., Mosconi, L., Sorbi, S., Nacmias, B., De, C. M. R. T. R., Fayyaz, M., ... Pupi, A. (2003). Brain metabolic differences between sporadic and familial Alzheimer's disease.Neurology, 61(8). . Publication link: 5151e1fa-779e-472f-aa58-874db9f7a7be
  • Hilker, R., Voges, J., Ghaemi, M., Lehrke, R., Rudolf, J., Koulousakis, A., ... Heiss, W. D. (2003). Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans. Movement Disorders, 18(1), 41-48. DOI:10.1002/mds.10297. Publication link: 3cb07c41-d4da-4abd-9b68-fad900c94103
  • Jacobs, A. H., Li, H., Winkeler, A., Hilker, R., Knoess, C., Rüger, A., ... Heiss, W. D. (2003). Pet-based molecular imaging in neuroscience. European Journal of Nuclear Medicine and Molecular Imaging, 30(7), 1051-1065. DOI:10.1007/s00259-003-1202-5. Publication link: 9d657322-a63b-49b0-90ed-c81ce7706040
  • Jacobs, A. H., Voges, J., Kracht, L. W., Dittmar, C., Winkeler, A., Thomas, A., ... Heiss, W. D. (2003). Imaging in gene therapy of patients with glioma. Journal of Neuro-Oncology, 65(3), 291-305. DOI:10.1023/B:NEON.0000003658.51816.3f. Publication link: 70c6d653-4e2d-4b32-a6be-a426f3e7a176
  • Sturm, V., Lenartz, D., Koulousakis, A., Treuer, H., Herholz, K., Klein, J. C., & Klosterkötter, J. (2003). The nucleus accumbens: A target for deep brain stimulation in obsessive-compulsive- and anxiety-disorders. Journal of Chemical Neuroanatomy, 26(4), 293-299. DOI:10.1016/j.jchemneu.2003.09.003. Publication link: 6d7aad07-a90c-4f64-8095-a8e12f8f7067
  • Herholz, K. G., Scheidhauer, K., & Ebmeier, K. P. (2003). Comparing HMPAO-SPECT and FDG-PET in Alzheimer's Disease. In SPECT in dementia. Basel. . Publication link: 499f9e2d-4b1d-4f99-b7e0-64e1a1bb753f
  • Herholz, K., Ebmeier, K. P., Darcourt, J., Dougall, N. J., Glasbus, M. F., KG, . U., ... Scheidhauer, K. (2003). Voxel-based approaches in clinical imaging. In SPECT in dementia. Basel. . Publication link: 4ef35e55-43ad-477c-873f-a49f725c1440


  • Herholz, K. G., Heiss, W. D., Thiel, A., & Kessler, J. (2002). Sprachaktivierung im PET bei isch,mischen Insulten und Hirntumoren.Zentralblatt fur Neurochirurgie, 63(4). . Publication link: 00e84a9e-d5f6-4097-90bd-8875f34facbf
  • Herholz, K. G., Hilker, R., Voges, J., Thiel, A., Ghaemi, M., Sturm, V., & Heiss, W. D. (2002). Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on-and off-conditions with FDG-PET.Journal of Neural transmission, 10. . Publication link: 5fea023e-c444-4b6b-92df-728a070fbd5c
  • Herholz, K. G., Huber, M., Habedank, B., Thiel, A., Muller-Kuppers, M., Ebel, H., ... Heiss, W. D. (2002). Differente Muster regionaler Hirnaktivitat nach emotionaler Stimulation bei alexithymen Patienten im Vergleich zu Normalpersonen. Eine Positronen-Emissions-Tomographische (PET) Studie mit 150-H2O und emotionaler Stimulierung durch autobiographische Erinnerung.Psychother. Psychosom. Med Psychol., 51(11). . Publication link: 45ad075b-7e4e-410b-8c41-23dad72d601d
  • Herholz, K., Salmon, E., Perani, D., Baron, J. C., Holthoff, V., Frölich, L., ... Heiss, W. D. (2002). Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. NeuroImage, 17(1), 302-316. DOI:10.1006/nimg.2002.1208. Publication link: 258d0817-005d-4109-8f2f-988dbfd62646
  • Herholz, K., Schopphoff, H., Schmidt, M., Mielke, R., Eschner, W., Scheidhauer, K., ... Ebmeier, K. (2002). Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease. Journal of Nuclear Medicine, 43(1), 21-26. . Publication link: 24a94ace-b8fc-44ba-a37b-9500170695eb
  • Hilker, R., Klein, C., Hedrich, K., Ozelius, L. J., Vieregge, P., Herholz, K., ... Heiss, W. D. (2002). The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: Evidence for enzymatic parkin function in humans. Neuroscience Letters, 323(1), 50-54. . Publication link: cfbf6b2c-3804-4d95-87fa-f0b55fb1f254
  • Jacobs, A. H., Winkeler, A., Dittmar, C., Gossmann, A., Deckert, M., Kracht, L., ... Heiss, W. D. (2002). Molecular and functional imaging technology for the development of efficient treatment strategies for gliomas. Technology in Cancer Research and Treatment, 1(3), 187-204. . Publication link: f9399e70-7765-4425-a313-0d56cbd3a158
  • Szelies, B., Sobesky, J., Pawlik, G., Mielke, R., Bauer, B., Herholz, K., & Heiss, W. D. (2002). Impaired benzodiazepine receptor binding in peri-lesional cortex of patients with symptomatic epilepsies studied by [11C]-flumazenil PET. European Journal of Neurology, 9(2), 137-142. DOI:10.1046/j.1468-1331.2002.00338.x. Publication link: fa690353-09f4-44ef-aa71-d74fef1e1608
  • Herholz, K. G., Kessler, J., Ehlen, P., Kalbe, E., Strotmann, T., Markowitsch, H. J., ... Herscovitch, P. (2002). Brain regions involved in learning face-name associations and the effects of age, performance, and learning phase.In Brain imaging using SPECT. San Diego, CA: Academic Press. . Publication link: b822245d-c51d-4a57-801d-3c3bd2f7f7ac
  • Herholz, K., Zundorf, G., KG, . U., Lercher, M., Wienhard, K., Bauer, B., ... Herscovitch, P. (2002). PET functional parametric images of acetylcholine esterase activity without blood sampling.In Brain imaging using PET. San Diego, CA: Academic Press. . Publication link: 48922597-50c7-42e6-b574-d90ba480b758


  • Herholz, K. G., Ghaemi, M., Rudolf, J., & Hilker, R. (2001). Increased pineal Fdopa uptake is related to severity of Parkinson's disease - a PET study. J. Pineal Res., 30 (4). . Publication link: 4035c048-7151-4700-bc0d-b30e19bc828f
  • Herholz, K. G., Huber, M., Siol, T., Lenz, O., Kohle, K., & Heiss, W. D. (2001). Activation of Thalamo-Cortical Systems in Post-Traumatic Flashbacks: A Positron Emission Tomography Study.Traumatology, 7(4). . Publication link: 9d118380-014d-4fcd-81f8-ed0d879d1e08
  • Herholz, K., Ehlen, P., Kessler, J., Strotmann, T., Kalbe, E., & Markowitsch, H. J. (2001). Learning face-name associations and the effect of age and performance: A PET activation study. Neuropsychologia, 39(6), 643-650. DOI:10.1016/S0028-3932(00)00144-5. Publication link: 147b21df-ccbc-48ec-ba6c-b31e2957e26d
  • Herholz, K., Lercher, M., Wienhard, K., Bauer, B., Lenz, O., & Heiss, W. D. (2001). PET measurement of cerebral acetylcholine esterase activity without blood sampling. European Journal of Nuclear Medicine, 28(4), 472-477. DOI:10.1007/s002590100492. Publication link: e2005eeb-8e08-47ae-ba24-2ef27bb533a8
  • Hilker, R., Klein, C., Ghaemi, M., Kis, B., Strotmann, T., Ozelius, L. J., ... Pramstaller, P. P. (2001). Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene. Annals of Neurology, 49(3), 367-376. DOI:10.1002/ana.74. Publication link: 44d23afb-9bfc-45bf-99df-23edf2124b9c
  • Jauss, M., Herholz, K., Kracht, L., Pantel, J., Hartmann, T., Jensen, M., ... Schröder, J. (2001). Frontotemporal dementia: Clinical, neuroimaging, and molecular biological findings in 6 patients. European Archives of Psychiatry and Clinical Neuroscience, 251(5), 225-231. DOI:10.1007/s004060170031. Publication link: 9ea2b66b-3f6f-4e94-ac40-238ed95a9509
  • Perani, D., Fazekas, F., Markus, H., Baumgartner, R. W., Baron, J. C., & Herholz, K. (2001). A survey of neuroimaging research in European neurological departments. European Journal of Neurology, 8(2), 111-117. DOI:10.1046/j.1468-1331.2001.00206.x. Publication link: d4d855e4-013b-4d03-a5ee-347edea5619c
  • Thiel, A., Herholz, K., Koyuncu, A., Ghaemi, M., Kracht, L. W., Habedank, B., & Heiss, W. D. (2001). Plasticity of language networks in patients with brain tumors: A positron emission tomography activation study. Annals of Neurology, 50(5), 620-629. DOI:10.1002/ana.1253. Publication link: 6ce6cb76-925f-4687-8713-7556830f3112


  • Herholz, K. G., Bartenstein, P., Grünwald, F., Kuwert, T., Tatsch, K., Sabri, O., ... Weiller, C. (2000). Clinical applications of single photon emission tomography in neurology. 2. Dementia, psychoses, inflammation, skull and brain injuries. Nuklearmedizin, 39( 8). . Publication link: c6ba8c74-6362-4df2-bf46-bdfbf9e67895
  • Herholz, K. G., Kessler, J., Mielke, R., Grond, M., & Heiss, W. D. (2000). Frontal lobe tasks do not reflect frontal lobe function in patients with probable Alzheimer's disease.Journal of Neuroscience, 1. . Publication link: f50fb7d2-4fc7-4d23-ac7f-11999e0c5d5f
  • Herholz, K., & Heiss, W. D. (2000). Functional imaging correlates of recovery after stroke in humans. Journal of Cerebral Blood Flow and Metabolism, 20(12), 1619-1631. . Publication link: 82a06b73-9ea5-4c73-8e11-5c59fd31cb37
  • Herholz, K., Bartenstein, P., Grunwald, F., Kuwert, T., Tatsch, K., Sabri, O., ... Weiller, C. (2000). Clinical applications of single photon emission tomography in neuromedicine. 1. Neuro-oncology, epilepsy, movement disorders, cerebrovascular disease. Nuklearmedizin, 39(7). . Publication link: 97887ad7-351b-45ff-8a80-8093fbca1e12
  • Herholz, K., Bauer, B., Wienhard, K., Kracht, L., Mielke, R., Lenz, O., ... Heiss, W. D. (2000). In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: Comparison with blood flow and glucose metabolism. Journal of Neural Transmission, 107(12), 1457-1468. DOI:10.1007/s007020070009. Publication link: 0a2bc067-99a1-46b6-b111-a08684046f5d
  • Herholz, K., Muzik, O., Da, S. E. A., Juhasz, C., Chugani, D. C., Shah, J., ... Chugani, H. T. (2000). Intracranial EEG vs. flumazenil and glucose PET in children with extratemporal lobe epilepsy.Neurology, 54. . Publication link: 45181ea3-3e0a-47ff-b593-88c5a62c7af8
  • Thiel, A., Pietrzyk, U., Sturm, V., Herholz, K., Hövels, M., & Schröder, R. (2000). Enhanced accuracy in differential diagnosis of radiation necrosis by positron emission tomography-magnetic resonance imaging coregistration: Technical case report. Neurosurgery, 46(1), 232-234. . Publication link: 7a3d9331-f9e2-46ea-b73b-886f4f9be9b6

Research projects