Professor Bill Deakin PhD, FRCPsych, FmedSci

Photograph of Bill Deakin

Professor of Psychiatry and Director NPU

Academic base:
Neuroscience and Psychiatry Unit
G.907 Stopford Building

Clinic base:
Department of Psychiatry
Rawnsley Building
Manchester Royal Infirmary

Research

Bill Deakin heads Neuroscience Research in the Division of Psychiatry. An important focus of his group is to use modern imaging techniques to directly visualise 5HT and glutamate working in the brain. Patients and volunteers lie in a magnetic resonance imaging scanner and the images show which parts of the brain respond to drugs chosen to probe 5HT or glutamate functioning and how it performs mental tasks. The group can show, for example, that a single dose of an antidepressant drug lights up areas of the brain concerned with anxiety responses and turns off other areas concerned with memory in healthy volunteers.

The group can also visualise how these neurotransmitters modify how the brain processes information. For example, viewing the image of a fearful face engaged regions of the brain concerned with emotion; a pre-dose of an antidepressant specifically affects this part of the response while not affecting fear responses in other brain regions. They are now investigating these effects in patients with anxiety, depression and antisocial behaviour.

Humans share the same set of about 30,000 genes including those concerned with 5HT and glutamate, but the particular copies we each carry from our mother and father are often slightly different and vary in their activity. Comparing brain responses in individuals with different variants is a new focus of the group’s work. For example, they used the internet to recruit more than 1000 individuals who completed a questionnaire about schizophrenia-like experiences. Those prone to such experiences were more likely to have an inactive variant of a neurotransmitter gene. This is a new approach to unravelling the role of genes in mental illness.

Biography

Professor Bill Deakin graduated in Medicine at Leeds University in 1973. He took an extra year in his training to obtain a 1st in Physiology and this excited his interest in neurobiology and the organisation of behaviour. He specialised in Psychiatry and joined the Clinical Research Centre at Northwick Park, London to further his training and worked on his PhD at the National Institute for Medical Research, Mill Hill. He was a MRC Training Fellow for 5 years. His PhD investigated how distinct 5HT (serotonin) neurone pathways in the rat brain have different functions in regulating adaptive, coping responses to stress.

Bill moved to the University of Manchester as Senior Lecturer in the early 1980s to continue 5HT research but in clinical experimental medicine with volunteers and patients with depression, anxiety and antisocial behaviour. One study funded by the Wellcome Trust involved measuring stress hormones in saliva from 500 mothers in the Wythenshawe estate and relating hormone levels to psycho-social adversity and brain 5HT functioning. Some 5HT pathways appear to be involved in anxiety and work to keep us out of risky or stressful situations while others are concerned with resilience in the face of long-term difficulties. 5HT also has important roles in addiction and social behaviour.

Bill’s group developed ideas about the role of glutamate in schizophrenia at first from studies in human post-mortem brain. More recently they have developed novel magnetic resonance imaging methods to track the action of drugs in the brain such as the glutamate antagonist ketamine. Bill is currently investigating how the antibiotic minocycline appears to improve the outcome of treatment for schizophrenia.

He is the experimental medicine lead of the UK Mental Health Research Network, a National Institute for Health Research Senior Investigator and a Fellow of the Academy of Medical Sciences. He has over 200 refereed publications and an H-factor of 60.
 

Publications

2012

  • Arnone, D., McKie, S., Elliott, R., Thomas, E., Downey, D., Juhasz, G., Williams, S., Deakin, J. & Anderson, I (2012). Increased amygdala responses to sad but not fearful faces in major depression: relation to mood state and pharmacological treatment. Am J Psychiatry, 169(8), 841-50. eScholarID:177548 | PMID:22854930 | DOI:10.1176/appi.ajp.2012.11121774
  • Chaudhry, I., Hallak, J., Husain, N., Minhas, F., Stirling, J., Richardson, P., Dursun, S., Dunn, G. & Deakin, B (2012). Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment. J Psychopharmacol, 26(9), 1185-93. eScholarID:177536 | PMID:22526685 | DOI:10.1177/0269881112444941
  • Elliott, R., Lythe, K., Lee, R., McKie, S., Juhasz, G., Thomas, E., Downey, D., Deakin, J. & Anderson, I (2012). Reduced medial prefrontal responses to social interaction images in remitted depression. Arch Gen Psychiatry, 69(1), 37-45. eScholarID:177547 | PMID:22213787 | DOI:10.1001/archgenpsychiatry.2011.139
  • Goulden, N., Elliott, R., Suckling, J., Williams, S., Deakin, J. & McKie, S (2012). Sample size estimation for comparing parameters using dynamic causal modeling. Brain Connect, 2(2), 80-90. eScholarID:177545 | PMID:22559836 | DOI:10.1089/brain.2011.0057
  • Goulden, N., McKie, S., Thomas, E., Downey, D., Juhasz, G., Williams, S., Rowe, J., Deakin, J., Anderson, I. & Elliott, R (2012). Reversed frontotemporal connectivity during emotional face processing in remitted depression. Biol Psychiatry, 72(7), 604-11. eScholarID:177546 | PMID:22682158 | DOI:10.1016/j.biopsych.2012.04.031
  • Green, S., Lambon Ralph, M., Moll, J., Deakin, J. & Zahn, R (2012). Guilt-Selective Functional Disconnection of Anterior Temporal and Subgenual Cortices in Major Depressive DisorderGuilt-Selective Functional Disconnection. Arch Gen Psychiatry, 1-8. eScholarID:177543 | PMID:22638494 | DOI:10.1001/archgenpsychiatry.2012.135
  • Green, S., Moll, J., Deakin, J., Hulleman, J. & Zahn, R (2012). Proneness to Decreased Negative Emotions in Major Depressive Disorder when Blaming Others rather than Oneself. Psychopathology, eScholarID:177544 | PMID:22890331 | DOI:10.1159/000338632
  • Hodkinson, D., de Groote, C., McKie, S., Deakin, J. & Williams, S (2012). Differential Effects of Anaesthesia on the phMRI Response to Acute Ketamine Challenge. Br J Med Med Res, 2(3), 373-385. eScholarID:177540 | PMID:22737655
  • Koychev, I., El-Deredy, W., Mukherjee, T., Haenschel, C. & Deakin, J (2012). Core dysfunction in schizophrenia: electrophysiology trait biomarkers. Acta Psychiatr Scand, 126(1), 59-71. eScholarID:177541 | PMID:22384856 | DOI:10.1111/j.1600-0447.2012.01849.x
  • Koychev, I., McMullen, K., Lees, J., Dadhiwala, R., Grayson, L., Perry, C., Schmechtig, A., Walters, J., Craig, K., Dawson, G., Dourish, C., Ettinger, U., Wilkinson, L., Williams, S., Deakin, J. & Barkus, E (2012). A validation of cognitive biomarkers for the early identification of cognitive enhancing agents in schizotypy: a three-center double-blind placebo-controlled study. Eur Neuropsychopharmacol, 22(7), 469-81. eScholarID:177539 | PMID:22137565 | DOI:10.1016/j.euroneuro.2011.10.005
  • Millan, M., Agid, Y., Brüne, M., Bullmore, E., Carter, C., Clayton, N., Connor, R., Davis, S., Deakin, B., DeRubeis, R., Dubois, B., Geyer, M., Goodwin, G., Gorwood, P., Jay, T., Joëls, M., Mansuy, I., Meyer-Lindenberg, A., Murphy, D., Rolls, E., Saletu, B., Spedding, M., Sweeney, J., Whittington, M. & Young, L (2012). Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov, 11(2), 141-68. eScholarID:177533 | PMID:22293568 | DOI:10.1038/nrd3628
  • Pap, D., Gonda, X., Molnar, E., Lazary, J., Benko, A., Downey, D., Thomas, E., Chase, D., Toth, Z., Mekli, K., Platt, H., Payton, A., Elliott, R., Anderson, I., Deakin, J., Bagdy, G. & Juhasz, G (2012). Genetic variants in the catechol-o-methyltransferase gene are associated with impulsivity and executive function: Relevance for major depression. Am J Med Genet B Neuropsychiatr Genet, eScholarID:177542 | PMID:23008195 | DOI:10.1002/ajmg.b.32098
  • Suckling, J., Barnes, A., Job, D., Brennan, D., Lymer, K., Dazzan, P., Marques, T., MacKay, C., McKie, S., Williams, S., Williams, S., Deakin, B. & Lawrie, S (2012). The Neuro/PsyGRID calibration experiment: identifying sources of variance and bias in multicenter MRI studies. Hum Brain Mapp, 33(2), 373-86. eScholarID:177538 | PMID:21425392 | DOI:10.1002/hbm.21210

2011

  • 1. McKie S, Richardson P, Elliott R, Bollm BA, Dolan MC, Williams SR, Anderson IM, Deakin. (2011). Mirtazapine antagonises the subjective, hormonal and neuronal effects of m-chlorophenylpiperazine (mCPP) infusion: A pharmacological-challenge fMRI (phMRI) study. NeuroImage, 58(2), 497-507. eScholarID:151753 | DOI:10.1016/j.neuroimage.2011.06.049
  • Anderson, I., Juhasz, G., Thomas, E., Downey, D., McKie, S., Deakin, J. & Elliott, R (2011). The effect of acute citalopram on face emotion processing in remitted depression: a pharmacoMRI study. Eur Neuropsychopharmacol, 21(1), 140-8. eScholarID:119076 | PMID:20599362 | DOI:10.1016/j.euroneuro.2010.06.008
  • Anderson, I., Shippen, C., Juhasz, G., Chase, D., Thomas, E., Downey, D., Toth, Z., Lloyd-Williams, K., Elliott, R. & Deakin, J (2011). State-dependent alteration in face emotion recognition in depression. Br J Psychiatry, eScholarID:119074 | PMID:21263011 | DOI:10.1192/bjp.bp.110.078139
  • Elliott, R., Zahn, R., Deakin, J. & Anderson, I (2011). Affective cognition and its disruption in mood disorders. Neuropsychopharmacology, 36(1), 153-82. eScholarID:119079 | PMID:20571485 | DOI:10.1038/npp.2010.77
  • Hoyle, D., Juhasz, G., Aso, E., Chase, D., del Rio, J., Fabre, V., Hamon, M., Lanfumey, L., Lesch, K., Maldonado, R., Serra, M., Sharp, T., Tordera, R., Toro, C. & Deakin, J (2011). Shared changes in gene expression in frontal cortex of four genetically modified mouse models of depression. Eur Neuropsychopharmacol, 21(1), 3-10. eScholarID:119073 | PMID:21030216 | DOI:10.1016/j.euroneuro.2010.09.011
  • Juhasz, G., Dunham, J., McKie, S., Thomas, E., Downey, D., Chase, D., Lloyd-Williams, K., Toth, Z., Platt, H., Mekli, K., Payton, A., Elliott, R., Williams, S., Anderson, I. & Deakin, J (2011). The CREB1-BDNF-NTRK2 Pathway in Depression: Multiple Gene-Cognition-Environment Interactions. Biol Psychiatry, eScholarID:119075 | PMID:21215389 | DOI:10.1016/j.biopsych.2010.11.019
  • Koychev, I., Barkus, E., Ettinger, U., Killcross, S., Roiser, J., Wilkinson, L. & Deakin, B (2011). Evaluation of state and trait biomarkers in healthy volunteers for the development of novel drug treatments in schizophrenia. J Psychopharmacol, 25(9), 1207-25. eScholarID:177534 | PMID:21994315 | DOI:10.1177/0269881111414450
  • Lazary, J., Juhasz, G., Anderson, I., Jacob, C., Nguyen, T., Lesch, K., Reif, A., Deakin, J. & Bagdy, G (2011). Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality. Eur Neuropsychopharmacol, 21(1), 63-70. eScholarID:119071 | PMID:20943350 | DOI:10.1016/j.euroneuro.2010.09.009
  • Mekli, K., Payton, A., Miyajima, F., Platt, H., Thomas, E., Downey, D., Lloyd-Williams, K., Chase, D., Toth, Z., Elliott, R., Ollier, W., Anderson, I., Deakin, J., Bagdy, G. & Juhasz, G (2011). The HTR1A and HTR1B receptor genes influence stress-related information processing. Eur Neuropsychopharmacol, 21(1), 129-39. eScholarID:119077 | PMID:20638825 | DOI:10.1016/j.euroneuro.2010.06.013
  • Rylands, A., McKie, S., Elliott, R., Deakin, J. & Tarrier, N (2011). A functional magnetic resonance imaging paradigm of expressed emotion in schizophrenia. J Nerv Ment Dis, 199(1), 25-9. eScholarID:119070 | PMID:21206243 | DOI:10.1097/NMD.0b013e3182043b87
  • Shokouhi, M., Barnes, A., Suckling, J., Moorhead, T., Brennan, D., Job, D., Lymer, K., Dazzan, P., Reis Marques, T., Mackay, C., McKie, S., Williams, S., Lawrie, S., Deakin, B., Williams, S. & Condon, B (2011). Assessment of the impact of the scanner-related factors on brain morphometry analysis with Brainvisa. BMC Med Imaging, 11, 23. eScholarID:177535 | PMID:22189342 | DOI:10.1186/1471-2342-11-23
  • Thomas, E., Elliott, R., McKie, S., Arnone, D., Downey, D., Juhasz, G., Deakin, J. & Anderson, I (2011). Interaction between a history of depression and rumination on neural response to emotional faces. Psychol Med, 1-11. eScholarID:119072 | PMID:21306660 | DOI:10.1017/S0033291711000043

2010

  • Alves-Neto, W., Guapo, V., Graeff, F., Deakin, J. & Del-Ben, C (2010). Effect of escitalopram on the processing of emotional faces. Braz J Med Biol Res, 43(3), 285-9. eScholarID:119088 | PMID:20209375 | DOI:10.1590/S0100-879X2010005000007
  • Benko, A., Lazary, J., Molnar, E., Gonda, X., Tothfalusi, L., Pap, D., Mirnics, Z., Kurimay, T., Chase, D., Juhasz, G., Anderson, I., Deakin, J. & Bagdy, G (2010). Significant association between the C(-1019)G functional polymorphism of the HTR1A gene and impulsivity. Am J Med Genet B Neuropsychiatr Genet, 153B(2), 592-9. eScholarID:85480 | PMID:19725031 | DOI:10.1002/ajmg.b.31025
  • da Costa Araújo, S., Body, S., Torres, L., Sanchez, C., Bak, V., Deakin, J., Anderson, I., Bradshaw, C. & Szabadi, E (2010). Choice between reinforcer delays versus choice between reinforcer magnitudes: Differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core. Behav Brain Res, eScholarID:85477 | PMID:20570596 | DOI:10.1016/j.bbr.2010.05.014
  • Elliott, R., Agnew, Z. & Deakin, J (2010). Hedonic and informational functions of the human orbitofrontal cortex. Cereb Cortex, 20(1), 198-204. eScholarID:85481 | PMID:19435707 | DOI:10.1093/cercor/bhp092
  • Elliott, R., Zahn, R., Deakin, J. & Anderson, I (2010). Affective Cognition and its Disruption in Mood Disorders. Neuropsychopharmacology, eScholarID:85475 | PMID:20571485 | DOI:10.1038/npp.2010.77
  • Goulden, N., McKie, S., Suckling, J., Williams, S., Anderson, I., Deakin, J. & Elliott, R (2010). A comparison of permutation and parametric testing for between group effective connectivity differences using DCM. Neuroimage, 50(2), 509-15. eScholarID:85478 | PMID:20004253 | DOI:10.1016/j.neuroimage.2009.11.059
  • Juhasz, G., Downey, D., Hinvest, N., Thomas, E., Chase, D., Toth, Z., Lloyd-Williams, K., Mekli, K., Platt, H., Payton, A., Bagdy, G., Elliott, R., Deakin, J. & Anderson, I (2010). Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology, 35(5), 1109-19. eScholarID:85479 | PMID:20043001 | DOI:10.1038/npp.2009.216
  • Koychev, I., El-Deredy, W., Haenschel, C. & Deakin, J (2010). Visual information processing deficits as biomarkers of vulnerability to schizophrenia: an event-related potential study in schizotypy. Neuropsychologia, 48(7), 2205-2214. eScholarID:85476 | PMID:20412812 | DOI:10.1016/j.neuropsychologia.2010.04.014
  • Palm, M., Elliott, R., McKie, S., Deakin, J. & Anderson, I (2010). Attenuated responses to emotional expressions in women with generalized anxiety disorder. Psychol Med, 1-11. eScholarID:119087 | PMID:20716396 | DOI:10.1017/S0033291710001455
  • Suckling J, Barnes A, Job D, Brenan D, Lymer K, Dazzan P, Marques TR, MacKay C, McKie S, Williams SR, Williams SC, Lawrie S, Deakin B. (2010). Power calculations for multicenter imaging studies controlled by the false discovery rate. Human Brain Mapping, 31(8), 1183-1195. eScholarID:116828 | DOI:10.1002/hbm.20927
  • Völlm, B., Richardson, P., McKie, S., Reniers, R., Elliott, R., Anderson, I., Williams, S., Dolan, M. & Deakin, B (2010). Neuronal correlates and serotonergic modulation of behavioural inhibition and reward in healthy and antisocial individuals. J Psychiatr Res, 44(3), 123-31. eScholarID:177537 | PMID:19683258 | DOI:10.1016/j.jpsychires.2009.07.005

2009

  • Benko A, Lazary J, Molnar E, Gonda X, Tothfalusi L, Papp D, Mirnics Z, Kurimai T, Chase, DS, Juhasz, G, Anderson, I, Deakin, JFW, Bagdy G. (2009). Significant association between the C(-1019)G functionalpolymorphism of the HTR1A gene and impulsivity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, eScholarID:1d20637
  • Bezzina, G., Cheung, T., Body, S., Deakin, J., Anderson, I., Bradshaw, C. & Szabadi, E (2009). Quantitative analysis of the effect of lesions of the subthalamic nucleus on intertemporal choice: further evidence for enhancement of the incentive value of food reinforcers. Behav Pharmacol, 20(5-6), 437-46. eScholarID:85484 | PMID:19667971 | DOI:10.1097/FBP.0b013e3283305e4d
  • da Costa Araújo, S., Body, S., Hampson, C., Langley, R., Deakin, J., Anderson, I., Bradshaw, C. & Szabadi, E (2009). Effects of lesions of the nucleus accumbens core on inter-temporal choice: further observations with an adjusting-delay procedure. Behav Brain Res, 202(2), 272-7. eScholarID:85483 | PMID:19463712 | DOI:10.1016/j.bbr.2009.04.003
  • Dunham, J., Deakin, J., Miyajima, F., Payton, A. & Toro, C (2009). Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains. J Psychiatr Res, 43(14), 1175-84. eScholarID:85485 | PMID:19376528 | DOI:10.1016/j.jpsychires.2009.03.008
  • Juhasz, G., Chase, D., Pegg, E., Downey, D., Toth, Z., Stones, K., Platt, H., Mekli, K., Payton, A., Elliott, R., Anderson, I. & Deakin, J (2009). CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms. Neuropsychopharmacology, 34(8), 2019-27. eScholarID:85486 | PMID:19242408 | DOI:10.1038/npp.2009.19
  • Juhasz, G., Lazary, J., Chase, D., Pegg, E., Downey, D., Toth, Z., Stones, K., Platt, H., Mekli, K., Payton, A., Anderson, I., Deakin, J. & Bagdy, G (2009). Variations in the cannabinoid receptor 1 gene predispose to migraine. Neurosci Lett, 461(2), 116-20. eScholarID:85482 | PMID:19539700 | DOI:10.1016/j.neulet.2009.06.021
  • Kleyn, CE, McKie, S, Ross, A, Montaldi, D, Gregory, LJ, Elliott, R, Isaacs, C, Anderson, I, Richards, HL, Deakin, JFW, Fortune, D, Griffiths, CEM. (2009). Diminished Neural and Cognitive Responses to Facial Expressions of Disgust in Patients with Psoriasis: A Functional Magnetic Resonance Imaging Study. Journal of Investigative Dermatology, 129(11), 2613-2619. eScholarID:1d21110 | DOI:10.1038/jid.2009.152
  • Kong Y, McKie S, Mukherjee TT, Deakin JFW, Williams SR. (2009). Analysis of connectivity in the resting state of the default-mode of brain function: a major role for the cerebellum? International Journal of Modelling, Identification and Control, 9(3), 236-246. eScholarID:1d21131
  • Völlm, B., Zhao, L., Richardson, P., Clark, L., Deakin, J., Williams, S. & Dolan, M (2009). A voxel-based morphometric MRI study in men with borderline personality disorder: preliminary findings. Crim Behav Ment Health, 19(1), 64-72. eScholarID:85487 | PMID:19172640 | DOI:10.1002/cbm.716
  • Deakin JFW. (2009). Brain sciences addiction and drugs; chapter 7 medicines for mental health. London: eScholarID:116790

2008

  • Anderson, I., McKie, S., Elliott, R., Williams, S. & Deakin, J (2008). Assessing human 5-HT function in vivo with pharmacoMRI. Neuropharmacology, 55(6), 1029-37. eScholarID:85490 | PMID:18621068 | DOI:10.1016/j.neuropharm.2008.06.029
  • Bezzina G, Body S, Cheung T, Hampson C, Bradshaw C, Szabadi E, Anderson I, Deakin JFW. (2008). Effect of disconnecting the orbital prefrontal cortex from the nucleus accumbens core on inter-temporal choice behaviour: a quantitative analysis. Behav Brain Res, 191( 2), eScholarID:1d32002 | DOI:10.1016/j.bbr.2008.03.041
  • Bezzina G, Body S, Cheung T, Hampson C, Deakin JFW, Anderson I, Szabadi E, Bradshaw C. (2008). Effect of quinolinic acid-induced lesions of the nucleus accumbens core on performance on a progressive ratio schedule of reinforcement: implications for inter-temporal choice. Psychopharmacology (Berl), 197( 2), eScholarID:1d32126 | DOI:10.1007/s00213-007-1036-0
  • Bezzina G, Boon F, Hampson C, Cheung T, Body S, Bradshaw C, Szabadi E, Anderson I, Deakin JFW. (2008). Effect of quinolinic acid-induced lesions of the subthalamic nucleus on performance on a progressive-ratio schedule of reinforcement: a quantitative analysis. Behav Brain Res, 195( 2), eScholarID:1d32398 | DOI:10.1016/j.bbr.2008.09.005
  • Deakin JFW, Lees J, McKie S, Williams SR, Hallak JEC, Dursun SM. (2008). Glutamate and the Neural Basis of the Subjective Effects of Ketamine:A Pharmaco–Magnetic Resonance Imaging Study. JAMA Psychiatry, 65(2), 154. eScholarID:1d21143 | DOI:10.1001/archgenpsychiatry.2007.37
  • Elliott R, Agnew Z, Deakin JFW. (2008). Medial orbitofrontal cortex codes relative rather than absolute value of financial rewards in humans. Eur J Neurosci, 27( 9), eScholarID:1d32508 | DOI:10.1111/j.1460-9568.2008.06202.x
  • Lubman DI, Allen N, Peters LA, Deakin JFW. (2008). Electrophysiological evidence that drug cues have greater salience than other affective stimuli in opiate addiction. Journal of Psychopharmacology, 22, 836-842. eScholarID:24074 | DOI:10.1177/0269881107083846
  • Oliveira R, Guimarães F, Deakin JFW. (2008). Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders. Braz J Med Biol Res, 41( 4), eScholarID:1d32207
  • Elliott R, Deakin JFW. (2008). Neuroscience of Human Reward. eScholarID:5d154

2007

  • Anderson, I., Del-Ben, C., Mckie, S., Richardson, P., Williams, S., Elliott, R. & Deakin, J (2007). Citalopram modulation of neuronal responses to aversive face emotions: a functional MRI study. Neuroreport, 18(13), 1351-5. eScholarID:85498 | PMID:17762711 | DOI:10.1097/WNR.0b013e3282742115
  • Anderson, I., Del-Ben, C., Mckie, S., Richardson, P., Williams, S., Elliott, R. & Deakin, J (2007). Citalopram modulation of neuronal responses to aversive face emotions: a functional MRI study. Neuroreport, 18(13), 1351-5. eScholarID:85512 | PMID:17762711 | DOI:10.1097/WNR.0b013e3282742115
  • Chaudhry, I., Husain, N., Khan, S., Badshah, S., Deakin, B. & Kapur, S (2007). Amoxapine as an antipsychotic: comparative study versus haloperidol. J Clin Psychopharmacol, 27(6), 575-81. eScholarID:85510 | PMID:18004123 | DOI:10.1097/jcp.0b013e31815a4424
  • Hallak J, Crippa J, Pinto J, Machado de Sousa J, Trzesniak C, Dursun S, McGuire P, Deakin JFW, Zuardi A. (2007). Total agenesis of the corpus callosum in a patient with childhood-onset schizophrenia. Arq Neuropsiquiatr, 65( 4B), 1216-9. eScholarID:1d32125
  • Lubman D, Allen N, Peters L, Deakin JFW. (2007). Electrophysiological evidence of the motivational salience of drug cues in opiate addiction. Psychol Med, 37( 8), 1203-9. eScholarID:1d32003 | DOI:10.1017/S0033291707009932
  • Toro C, Deakin JFW. (2007). Adult neurogenesis and schizophrenia: a window on abnormal early brain development? Schizophr Res, 90( 1-3), 1-14. eScholarID:1d31921 | DOI:10.1016/j.schres.2006.09.030
  • Toro C, Hallak J, Dunham J, Leite J, Sakamoto A, Guarnieri R, Fong V, Deakin JFW. (2007). The NR1 N-methyl-D-aspartate subunit and brain-derived neurotrophic factor in temporal lobe epilepsy hippocampus: a comparison of patients with and without coexisting psychiatric symptoms. Epilepsia, 48( 12), 2352-6. eScholarID:1d32509 | DOI:10.1111/j.1528-1167.2007.01194.x
  • Völlm, B., Richardson, P., McKie, S., Elliott, R., Dolan, M. & Deakin, B (2007). Neuronal correlates of reward and loss in Cluster B personality disorders: a functional magnetic resonance imaging study. Psychiatry Res, 156(2), 151-67. eScholarID:85511 | PMID:17920821 | DOI:10.1016/j.pscychresns.2007.04.008

2006

  • Elliott R, Vollm BA, A Drury, McKie S, Richardson PC, Deakin JFW. (2006). Cooperation with another player in a financially rewarded guessing game activates regions implicated in theory of mind. Social Neuroscience, 1, eScholarID:1d14205
  • Toro CT, Deakin JFW. (2006). Adult neurogenesis and schizophrenia: a window on abnormal early brain development? Schizophrenia Research, E-pub ahead of print, E-pub ahead of print. eScholarID:1d14515
  • Toro CT, Hallak J, Dunham J, Deakin JFW. (2006). Glial fibrillary acidic protein and glutamine synthetase in subregions of prefrontal cortex in schizophrenia and mood disorder. Neuroscience Letters, 404, 276-281. eScholarID:1d14516 | DOI:10.1016/j.neulet.2006.05.067
  • Vollm BA, Richardson PC, McKie S, Deakin JFW, Elliott R, Anderson I. (2006). Serotonergic Modulation of Neuronal Responses to Behavioural Inhibition and Reinforcing Stimuli: An fMRI Study in Healthy Volunteers. European Journal of Neuroscience, 23 (2), eScholarID:1d12373 | DOI:10.1111/j.1460-9568.2005.04571.x
  • Vollm BA, Taylor ANW, Richardson PC, Corcoran R, Stirling J, McKie S, Deakin JFW, Elliott R. (2006). Neuronal Correlates of Theory of Mind and Empathy: A Functional Magnetic Resonance Imaging Study in a Nonverbal Task. Neuroimage, 29, 90-98. eScholarID:1d12297 | DOI:10.1016/j.neuroimage.2005.07.022

2005

  • Deakin JFW, Elliott R. (2005). Role of the Orbitofrontal Cortex in Reinforcement Processing and Inhibitory Control: Evidence from FMRI Studies in Healthy Human Subjects. International Review of Neurobiology, eScholarID:1d9063
  • Del-Ben C, Deakin JFW, McKie S, Delvai N, Williams SR, Elliott R, Dolan M, Anderson I. (2005). The effect of Citalopram pretreatment on neuronal responses to neuropsychological tasks in normal volunteers: an FMRI study. Neuropsychopharmacology, 30, 1724-1734. eScholarID:1d11106 | DOI:10.1038/sj.npp.1300728
  • Dursun SM, Hallak J, Haddad P, Leahy A, Byrne A, Strickland P, Anderson I, Zuardi A, Deakin JFW. (2005). Clozapine monotherapy for catatonic schizophrenia: should clozapine be the treatment of choice, with catatonia rather than psychosis as the main therapeutic index? J Psychopharmacol, 19( 4), 432-3. eScholarID:1d29803
  • Ersche, K., Fletcher, P., Lewis, S., Clark, L., Stocks-Gee, G., London, M., Deakin, J., Robbins, T. & Sahakian, B (2005). Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals. Psychopharmacology (Berl), 180(4), 612-23. eScholarID:85505 | PMID:16163533 | DOI:10.1007/s00213-005-2205-7
  • Guarnieri, R, Wichert-Ana, L, Hallak, J, Velasco, T, Walz, R, Kato, M, Alexandre, V, Terra-Bustamante, V, Bianchin, M, Zuardi, A, Deakin, JFW, Sakamoto, A. (2005). Interictal SPECT in patients with mesial temporal lobe epilepsy and psychosis: a case-control study. Psychiatry Res, 138( 1), 75-84. eScholarID:1d29960 | DOI:10.1016/j.pscychresns.2004.10.003
  • Kheramin S, Body S, Herrera F, Bradshaw C, Szabadi E, Deakin JFW, Anderson I. (2005). The effect of orbital prefrontal cortex lesions on performance on a progressive ratio schedule: implications for models of inter-temporal choice. Behav Brain Res, 156( 1), 145-52. eScholarID:1d9323
  • Lythe K, Anderson I, Deakin JFW, Elliott R, Strickland PL. (2005). Lack of behavioural effects after acute tyrosine depletion in healthy volunteers. Journal of Psychopharmacology, eScholarID:1d9066
  • McKie S, Del-Ben C, Elliott R, Williams SR, Delvai NA, Anderson I, Deakin JFW. (2005). Neuronal effects of acute Citalopram detected by pharmacoMRI (pMRI). Psychopharmacology, 180, 680-686. eScholarID:1d10428 | DOI:10.1007/s00213-005-2270-y
  • Richell RA, Deakin JFW, Anderson I. (2005). Effect of acute Tryptophan depletion on the response tocontrollable and uncontrollable noise stress. BIOLOGICAL PSYCHIATRY, 57 (3), 295-300. eScholarID:1d11058 | DOI:10.1016/j.biopsych.2004.10.010
  • Toro C, Deakin JFW. (2005). NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder. Schizophr Res, 80 (2-3), 323-30. eScholarID:1d12188 | DOI:10.1016/j.schres.2005.07.003

2004

  • Bantick R, Montgomery A, Bench C, Choudhry T, Malek N, McKenna P, Quested D, Deakin JFW, Grasby P. (2004). A positron emission tomography study of the 5-HT1A receptor in schizophrenia and during clozapine treatment. J Psychopharmacol, 18( 3), 346-54. eScholarID:1d31183
  • Ranote S, Elliott R, Abel K, Mitchell R, Deakin JFW, Appleby L. (2004). The neural basis of maternal responsiveness to infants: an fMRI study. Neuroreport, 15( 11), eScholarID:1d9308
  • Vollm, BA, Richardson, PC, Stirling, J, Elliott, R, Dolan, M, Chaudhry, I, Del Ben, C, McKie, S, Anderson, I, Deakin, JFW. (2004). Neurobiological substrates of antisocial and borderline personality disorder: preliminary results of a functional MRI study. Criminal Behaviour and Mental Health, 14, eScholarID:1d9067 | DOI:10.1002/cbm.559

2003

  • Deakin JFW. (2003). Depression and antisocial personality disorder: two contrasting disorders of 5HT function. Jounal of Neural Transmission, 64, 79-93. eScholarID:1d25345
  • Elliott R, Newman JL, Longe OA, Deakin JFW. (2003). Differential response patterns in the striatum and orbitofrontal cortex to financial reward in humans: a parametric fMRI study. Journal of Neuroscience, 23 (1), 303-307. eScholarID:1d5992
  • Gabrobvska-Johnson VS, Scott M, Jeffries S, Thaker N, Baldwin RC, Burns AS, Lewis SW, Deakin JFW. (2003). Right-hemisphere encephalopathy in elderly subjects with schizophrenia evidence from neuropsychological and brain imaging studies. Psychopharmacology (Berl), 169 (3-4), 367-375. eScholarID:1d6408 | DOI:10.1007/s00213-003-1524-9
  • Kheramin S, Body S, Ho MY, Velazquez-Martinez DN, Bradshaw CM, Szabadi E, Deakin JFW, Anderson I. (2003). Role of the orbital prefrontal cortex in choice between delayed and uncertain reinforcers: a quantitative analysis. BEHAVIOURAL PROCESSES, 64, 3, eScholarID:1d9939
  • Strickland PL, John S, Payton A, Ollier W, Deakin JFW. (2003). Do polymorphic genes influence prolactin responses to dexfenfluramine? American Journal Of Medical Genetics, 120A, 4. eScholarID:17d161
  • StricklandP.L, John S, Payton A, Worthington J, Ollier WER, Deakin JFW. (2003). Do genetic polymorphisms of serotonin (5-HT) neurotransmission influence function in humans? American Journal of Medical Genetics, 120A(4), 566-567. eScholarID:17d816

2002

  • Clarke L, Elliott R, Kulkarni B, Deakin JFW, Williams S, Anderson I. (2002). 5-HT Modulation of Behavioural Inhibition and Localised Brain Activation. A Functional and Pharmacological MRI Study. eScholarID:2d888
  • Anderson I, Clark L, Elliott R, Kulkarni B, Williams SR, Deakin JFW. (2002). 5-HT2C receptor activation by m-Chlorophenylpiperazine detected in humans with fMRI. NeuroReport, 13 (12), 1547-1551. eScholarID:1d23706
  • Chaudhry I B, Soni S D, Hellewell JSE, Deakin JFW. (2002). Effects of the 5HT antagonist cyproheptadine on neuropsychological function in chronic schizophrenia. Schizophrenia Research, 52, 17-24. eScholarID:1d23699
  • Crawford TJ, Bennett D, Lekwuwa G, Shaunak S, Deakin JFW. (2002). Cognition and the inhibitory control of saccades in schizophrenia and Parkinson’s disease. Progressive Brain Research, 140, 449-466. eScholarID:1d25344 | DOI:10.1016/S0079-6123(02)40068-4
  • Deakin JFW, Dursun SM. (2002). Optimizing Antidepressant Treatment: Efficacy and Tolerability. International Clinical Psychology, 17(1), 13-24. eScholarID:1d25371
  • Deakin JFW, Toro CT, Law AJ. (2002). Glutamate system gene expression in schizophrenia. European Psychiatry: the Journal of the Association of European Psychiatrists, 17(1), 24-24. eScholarID:1d25340
  • Dolan M, Deakin JFW, Roberts N, Anderson I. (2002). Quantitative frontal and temporal structural MRI studies in personality-disordered offenders and control subjects. Psychiatry Research: Neuroimaging, 116, 133-149. eScholarID:1d25722 | DOI:10.1016/S0925-4927(02)00085-9
  • Dolan M, Deakin JFW, Roberts N, Anderson I. (2002). Serotonergic and cognitive impairment in impulsive aggressive personality disordered offenders: are there implications for treatment? Psychological Medicine, 32, 105-117. eScholarID:1d23783
  • Garland MR, Strickland PL, Deakin JFW. (2002). Cortisol, stress and depression. Authors’ reply. British Journal of Psychiatry, 181, 348-349. eScholarID:1d25343 | DOI:10.1192/bjp.181.4.348
  • Kheramin S, Body S, Mobini S, Ho MY, Velazquez-Martinez DN, Bradshaw CM, Szabadi E, Deakin JFW, Anderson I. (2002). Effects of quinolinic acid-induced lesions of the orbital prefrontal cortex on inter-temporal choice: a quantitative analysis. Psychopharmacology, 165(1), 9-17. eScholarID:1d25318 | DOI:10.1007/s00213-002-1228-6
  • Mobini S, Body S, Ho MY, Bradshaw CM, Szabadi E, Deakin JFW, Anderson I. (2002). Effects of lesions of the orbitofrontal cortex on sensitivity to delayed and probabilistic reinforcement. Psychopharmacology, 160(3), 290-298. eScholarID:1d25320 | DOI:10.1007/s00213-001-0983-0
  • Morriss RK, Robson MJ, Deakin JFW. (2002). Neuropsychological performance and noradrenaline function in chronic fatigue syndrome under conditions of high arousal. Psychopharmacology, 163, 166-173. eScholarID:1d25341 | DOI:10.1007/s00213-002-1129-8
  • Strickland PL, Deakin JFW, Percival C, Dixon J, Gater RA, Goldberg DP. (2002). Bio-social origins of depression in the community - Interactions between social adversity, cortisol and serotonin neurotransmission. BRITISH JOURNAL OF PSYCHIATRY, 180, eScholarID:1d9962
  • Strickland PL, Deakin JFW, Percival C, Dixon J, Gater RR, Goldberg D. (2002). Bio-social origins of depression in the community. Interactions between social adversity, cortisol and serotonin neurotransmission. Br J Psychiatry, 180, 168-173. eScholarID:1d2855 | DOI:10.1192/bjp.180.2.168
  • Strickland PL, Dixon J, Percival C, Deakin JFW, Goldberg D P. (2002). 5HT and cortisol interactions and the psychosocial origins of depression. British Journal Of Psychiatry, 180, 168-173. eScholarID:1d24004 | DOI:10.1192/bjp.180.2.168
  • Strickland PL, Rostron E, Haddad P, Deakin JFW, Dursun SM. (2002). Assessment and management of "compulsive scratching" in schizophrenia with chronic renal failure. Canadian Journal of Psychiatry, 47 (5), 484-485. eScholarID:1d24009
  • Tarrier N, Sommerfield C, Connell J, Deakin JFW, Pilgrim H, Reynolds M. (2002). The psychophysiological responses of PTSD patients: habituation, responses to stressful and neutral vignettes and association with treatment outcome. Cognitive & Behavioural Psychotherapy, 30, 129-142. eScholarID:1d25266
  • Anderson I, Clark L, Elliott R, Kulkarni B, Williams S, Deakin JFW. (2002). 5-HT2C receptor activation detected in humans by fMRI. Neuroimage, 16(3), S57. eScholarID:17d160
  • Clark L, Elliott R, Deakin JFW, Anderson I. (2002). Preference conditioning using supraliminal and subliminal monetary reinforcers in normal volunteers. Journal of Psychopharmacology, 16(3), A26. eScholarID:17d220
  • Haddad P M, Strickland PL, Anderson I, Deakin JFW, Dursun SM. (2002). Effects of MDMA (ecstasy) use and abstention on serotonin neurons. Lancet, 359, 1616-1617. eScholarID:17d129
  • Lythe K, Anderson I, Strickland PL, Deakin JB, Aitken MRF, Deakin JFW. (2002). Effects of acute tyrosine depletion on mood, cognition and behaviour in healthy volunteers. Journal of Psychopharmacology, 16(3), A42. eScholarID:17d158
  • Strickland PL, Rostron E, Haddad P, Deakin JFW, Dursun SM. (2002). Assessing and managing compulsive scratching in schizophrenia with chronic renal failure. Canadian Journal of Psychiatry, 47(5), 484-485. eScholarID:17d618

2001

  • Law AJ, Deakin JFW. (2001). Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses. NeuroReport, 12(13), 2971-2974. eScholarID:1d25338

  • eScholarID:115824
  • 3-9. eScholarID:117730
  • Human Brain Mapping, eScholarID:115856
  • Human Brain Mapping, 1183-95. eScholarID:115827

Research projects