About the study
Aims of the study
In this study we will look at whether we can find differences in the way social knowledge is stored in people with or without a history of depression. If you have had depression before, we will ask you to participate in follow-up interviews over 14 months to see whether our imaging measures can predict whether you remain stable or get another episode of depression over this period. This project aims to include 120 men and women who have previously suffered with depression, and 60 people who have never had depression.
This project is funded by the Medical Research Council (MRC) and has been approved by South Manchester Research Ethics Committee, Ref. 07/H1003/194.
What is the study about?
During everyday dealings with other people, we automatically think about their behaviour and our own and this affects how we feel about ourselves and other people. For example imagine you said something to a friend which you realise may have hurt their feelings; you might well feel guilty or shameful afterwards and begin to wonder if you were a tactless or rude person. Nonetheless, as yet little is known about how the brain works these things out. However, it is important to find out because this kind of thinking may become very negative in people with a tendency to depression.
If we better understood how the brain processes the type of information that enables people to cooperate socially and reflect and have feelings about such social interactions, we think there is a good chance that we would learn more about the causes of depression. Our research could give us new ideas about how to treat depression.